期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 16, 页码 4111-4119出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf300521j
关键词
poly(lactic acid); controlled release; metazachlor; oil-in-water solvent evaporation technique; microparticles; kinetics
资金
- Internal Grant Agency of Tomas Bata University in Zlin [IGA/FT/2012/005]
- European Regional Development Fund (ERDF)
- national budget of Czech Republic [CZ.1.05/2.1.00/03.0111]
- Grant Agency of Czech Republic [GACR P108/10/0200]
- Ministry of Education, Youth and Sports of the Czech Republic [ME09072]
The preemergence chloroacetamide herbicide metazachlor was encapsulated in biodegradable low molecular weight poly(lactic acid) micro- and submicroparticles, and its release to the water environment was investigated. Three series of particles, S, M, and L, varying in their size (from 0.6 to 8 mu m) and with various initial amounts of the active agent (5%, 10%, 20%, 30% w/w) were prepared by the oil-in-water solvent evaporation technique with gelatin as biodegradable surfactant. The encapsulation efficiencies reached were about 60% and appeared to be lower for smaller particles. Generally, it was found that the rate of herbicide release decreased with increasing size of particles. After 30 days the portions of the herbicide released for its highest loading (30% w/w) were 92%, 56%, and 34% for about 0.6, 0.8, and 8 mu m particles, respectively. The release rates were also lower for lower herbicide loadings. Metazachlor release from larger particles tended to be a diffusion-controlled process, while for smaller particles the kinetics was strongly influenced by an initial burst release.
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