期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 42, 页码 10546-10554出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf302809k
关键词
apple; triterpene; procyanidin; nutrigenomics; inflammation
资金
- New Zealand Ministry for Science and Innovation as part of Nutrigenomics New Zealand [C06X0702]
- Fond National de la Recherche Luxembourg [PDR 08033]
We evaluated the potential of apple to reduce inflammation. Phenolic compounds and triterpenes were analyzed in 109 apple cultivars. Total phenolics ranged from 29 to 7882 mu g g(-1) of fresh weight (FW) in the flesh and from 733 to 4868 mu g g(-1) FW in the skin, with flavanols including epicatechin and procyanidins as major components. Ursolic (44.7 to 3522 mu g g(-1) FW) and oleanolic (47.2 to 838 mu g g(-1) FW) acids dominated the skin triterpene profile. Five chemically contrasting cultivars were fractionated and their immune-modulating activity measured using two cell-based assays targeting key points in the inflammation process. Cultivars exhibiting high contents of procyanidins were the most potent at inhibiting NF-kappa B while triterpene-rich fractions reduced the promoter activity of the gene of TNF alpha. This study provides new insights into how apple genetic diversity could be used to alleviate inflammation.
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