期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 19, 页码 4833-4840出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf3001108
关键词
resveratrol; glucuronide metabolites; sulfate metabolites; dihydroresveratrol; liver; adipose tissue; skeletal muscle
资金
- INGENIO-CONSOLIDER Program, Fun-C-Food [CSD2007-063]
- Instituto de Salud Carlos III (RETIC PREDIMED)
- Spanish Ministerio de Ciencia e Innovacion [AGL2008-1005-ALI, AGL2009-13906-C02-01]
- de Spanish Ministerio de Economia y Competitividad [AGL2011-27406-ALI]
- Government of the Basque Country [IT-386-10]
- University of the Basque Country (UPV/EHU) [UFI11/32]
- Generalitat de Catalunya
- Education Ministry [FPU AP2008-01922]
- Ministry of Science and Innovation [CD09/00134]
This study aimed to characterize resveratrol metabolite profiles in liver, skeletal muscle, and adipose tissue in rats treated for 6 weeks with 6, 30, or 60 mg of trans-resveratrol/kg body weight/d. Resveratrol metabolites were quantified by liquid chromatography-tandem mass spectrometry. The greatest number of metabolites was found in liver followed by adipose tissue. A great number of metabolites in muscle was below the limit of detection. The amounts of sulfate conjugates tended to increase when resveratrol dosage was enhanced, while the glucuronide ones increased only between 6 and 30 mg/kg/d. Microbiota metabolites were detected in higher amounts than resveratrol conjugates in liver, while the opposite occurred in adipose tissue and muscle. So, the largest amounts of resveratrol metabolites were found in liver, intermediate amounts in adipose tissue, and the lowest amounts in muscle. Sulfate conjugates, but not glucuronides, showed a dose response pattern. Microbiota metabolites were predominant in liver.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据