期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 35, 页码 8544-8551出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf302746m
关键词
Phenanthrene-based antofine derivatives; antiviral activity; tobacco mosaic virus; structure-activity relationship; TMV; SAR
资金
- National Key Project for Basic Research [2010CB126100]
- National Natural Science Foundation of China [21132003, 21121002]
- China Postdoctoral Science Foundation [2011M500519]
- National Key Technology Research and Development Program [2011BAE06B02-17, 2012BAK25B03-3]
- Tianjin Natural Science Foundation [11JCZDJC20500]
On the basis of our previous structure activity relationship (SAR) and antiviral mechanism studies, a series of phenanthrene-based antofine derivatives (1-12 and 18-50) were designed targeting tobacco mosaic virus (TMV) RNA and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 19 and 27 displayed higher activity than commercial Ribavirin, thus emerging as potential inhibitors of plant virus. The novel concise structure provides another new template for antiviral studies.
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