期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 59, 期 23, 页码 12342-12351出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf202821u
关键词
beta-cryptoxanthin; Satsuma mandarin (Citrus unshiu Marc); TSOD; adipocyte
The carotenoid beta-cryptoxanthin (beta-CRX) is abundant in Satsuma mandarins (Citrus unshiu Marc). Several studies have shown a relationship between Satsuma mandarin consumption and a low risk of several diseases, for example, diabetes, gout, and hypertension, suggesting beta-CRX involvement in disease prevention. We investigated the effect of beta-CRX on mildly obese males. beta-CRX administration reduced visceral adipose tissue, body weight, and abdominal circumference. However, the detailed mechanism by which beta-CRX mediates these changes remains unknown. To identify this mechanism, we used an obese model mouse (TSOD). Oral beta-CRX administration repressed body weight, abdominal adipose tissue weight, and serum lipid concentrations in TSOD; these results are identical to previous human trial results. beta-CRX administration significantly repressed adipocyte hypertrophy. Gene expression analysis strongly indicated that beta-CRX can alter cytokine secretion and cell proliferation. These results suggest that beta-CRX derived from Satsuma mandarins can help prevent obesity by repressing hypertrophy of abdominal adipocytes.
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