期刊
NANO LETTERS
卷 15, 期 10, 页码 6919-6925出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b02859
关键词
Peptide bioink; ultrashort peptides; stimuli-responsive self-assembly; nanofibrous scaffold; bioprinting; smart biomaterials
类别
资金
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells and tissues. We report the first peptide bioinks-lysine-containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional hydrogels with unprecedented stiffness of up to 40 kPa. These biocompatible scaffolds support the three-dimensional culture of human stem cells and differentiation of primary cells into organotypic (gastrointestinal and skin) structures for high-throughput screening, diagnosis, and tissue engineering.
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