期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 59, 期 21, 页码 11442-11448出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf2021804
关键词
blackberry; carbon tetrachloride; oxidative stress; antioxidant enzyme; lipid peroxidation; NF-E2-related factor-2 (Nrf2)
资金
- Ministry of Education, Science and Technology (MEST), Republic of Korea
The aim of this study was to investigate the protective ability Of blackberry extract (BE),against oxidative stress in carbon tetrachloride (CCl4)-treated rats The results showed that treatment with BE attenuated lipid peroxidation that was increased by CCl4 and also markedly recovered the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), that were decreased by CCl4 BE also elevated the protein expression levels of NF-E2-related factor-2 (Nrf2), CuZnSOD, MnSOD, GPx-1/2, and heme oxygenase-1 (HO-1), but not that of catalase Furthermore, the administration of BE significantly attenuated the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) that were increased by CCl4 Therefore, the present study suggests that BE possesses significant protective effects against in vivo oxidative stress
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