期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 59, 期 10, 页码 5335-5341出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf2004157
关键词
tomato; soy; isoflavones; carotenoids; prostate cancer; bioavailability
资金
- USDA [2005-03750]
- University of Illinois Division of Nutritional Sciences Margin of Excellence
The efficacy of combinations of food for enhanced anticancer activity is of clinical interest, but there is limited information on the effect of combined consumption on bioactive bioavailability. Male Copenhagen rats consumed diets containing 10% tomato powder (TP), 2% soy germ (SG), neither, or a combination (TP+SG) for 25 weeks (n = 63) or 7 days (n = 24). After 7 days, serum carotenoids were significantly lower after TP+SG feeding compared to TP alone. After 25 weeks, the TP+SG group had significantly lower lycopene and beta-carotene concentration in the testes, seminal vesicles, and ventral prostate compared to the TP group and significantly higher urinary isoflavone excretion compared to the SG group. These differences were not explained by mRNA expression of scavenger receptor class B type I, carotene 15,15'-monooxygenase I, carotene 9',10'-monooxygenase II, or activity of hepatic detoxification enzymes. The results suggest interactions between soy germ and tomato powder that enhance isoflavone absorption but reduce carotenoid bioavailability.
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