Lipoic Acid: An Immunomodulator That Attenuates Glycinin-Induced Anaphylactic Reactions in a Rat Model

The purpose of this study was to evaluate the attenuation effects of consuming a small dose of lipoic acid on soybean glycinin-induced hypersensitivity using a rat model. Sensitized by gavage with glycinin, weaned rats were orally supplemented with the diet containing 12.5 mu g of lipoic acid/g (per diet). Results showed that untreated, sensitized rats demonstrated an increase in the level of serum IgE, the level of histamine release, and incidence of diarrhea and reduced growth performance compared with the controls (P < 0.05). Lipoic acid significantly (P < 0.05) improved growth performance while reducing mast cell numbers, the level of serum IgE, and the level of histamine release. Lipoic acid supplementation altered the balance of cytokines, attenuated the Th2-type immune response, and amended the ratio of CD4(+) to CD8(+) T cells (P < 0.05). Our results suggest that a small dose of lipoic acid has the potential to be an immunomodulator to prevent soybean-induced allergies.