期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 58, 期 22, 页码 11525-11533出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf1031789
关键词
Domoic acid; shellfish poisoning; determination; sample preparation; HPLC; CE; CEC
资金
- National Nature Sciences Foundation of China [20735002, 20877019, 40940026]
- Foundation from the Sino-German Center for Research Promotion
- Ministry of Education of China [708056]
- Nature Sciences Funding of Fujian Province [2008J0228, 2007F5068]
- China Scholarship Council
Domoic acid (DA), a neurotoxic amino acid produced by some strains of phytoplankton, is responsible for the human toxic syndrome amnesic shellfish poisoning. This exocitotoxin results in neuronal degeneration and necrosis in specific regions of the hippocampus. Because DA accumulates mostly in shellfish, causing outbreaks in different countries, screening for DA has been carried out with various assays. Although bioassays and immunoassays have been developed, several liquid chromatographic methods for the determination of DA in different matrices such as shellfish, algae, or seawater have been reported. Additionally, other alternative methods such as capillary electrophoresis and capillary electrochromatography have been described. This paper summaries the toxicology, the chemistry, and the developed determination methods of DA.
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