期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 58, 期 23, 页码 12337-12342出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf103440s
关键词
Phenanthrene-based tylophorine derivatives; synthesis; antiviral activities; tobacco mosaic virus; Inhibitors
资金
- National Key Project for Basic Research [2010CB126100]
- National Natural Science Foundation of China [20872072]
- China Postdoctoral Science Foundation [20090460057]
A series of C9-substituted phenanthrene-based tylophorine derivatives (PBTs) were designed, synthesized, and first evaluated for their antiviral activities against tobacco mosaic virus (TMV). These compounds contain a phenanthrene core structure and can be synthesized some efficiently with excellent y elds compared with tylophorine alkaloid. The bioassay results show that some of these compounds exhibited higher antiviral activity against TMV in vivo than tylophorine and commercial Ningnanmycin. Especially, compounds 3, 4, 9, 13, and 16 emerged as potential inhibitors of plant virus. These new findings demonstrate that these phenanthrene-based tylophorine derivatives (PBTs) represent another new template for antiviral studies and could be considered for novel therapy against plant virus infection.
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