期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 57, 期 20, 页码 9481-9488出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf9021459
关键词
Nuclear factor kappa B; cereal extract; phenolic acids
资金
- TINE BA
- Lantmannen Cerealia
- Norwegian Agricultural Authority (SLF)
- Norwegian Research Council (NFR)
- IKBM (Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Science)
The transcription factor nuclear factor kappa B (NF-kappa B) plays a critical role in stress, immune, and inflammatory responses, and the modulation of its activity can be a potentially effective preventive strategy for controlling certain diseases. Cereal grains contain phenolic compounds in concentrations comparable to those in fruits and vegetables, well-known for their beneficial effect on human health. In this study we aimed to examine the effect of different phenolic extracts from barley, oat, wheat, and buckwheat on the modulation of basal and lipopolysaccharide (LPS)-induced NF-kappa B activity and elucidate the role of phenolic acids in this modulation. Three extracts were prepared: extracts of free phenolic compounds (M1), extracts of free phenolic acids (M2), and extracts of bound phenolic acids (HY). Generally, extracts M2 showed the highest effect on modulation of NF-kappa B activity with strong inhibition of LPS-induced NIF-kappa B activity at all concentrations and of the basal NF-kappa B activity at concentrations equal to or lower than 3 mg/mL. Most of extracts M1 and HY slightly increased both the basal and the LPS-induced NF-kappa B activation. However, at the highest concentrations (3 or 15 mg/mL) extracts HY inhibited LPS-induced NF-kappa B activation. Similar experiments with standard solutions of phenolic acids indicated their ability to modulate the NF-kappa B activity.
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