期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 156, 期 -, 页码 171-177出版社
ELSEVIER
DOI: 10.1016/j.jad.2013.11.025
关键词
Depression; High-fat diet; Corticosterone; AICAR; Exercise
资金
- National Natural Science Foundation of China
Major depressive disorder (MOD) and type II diabetes mellitus (T2DM) are highly co-morbid, and there may be a bi-directional connection between the two. Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HUD) and corticosterone (CURT). 5-Aminoimidazole-4-carboxamide 1 d ribofuranoside (AICAR), a pharmacological activator of AMP-activated protein kinase (AMPK), was originally used to improve insulin resistance (IR). Interestingly, our results show a clear potential for AICAR as a putative antidepressant with a chronic action on the DlR mice. In contrast to the traditional antidepressants. AICAR as a promising antidepressant avoids reducing insulin actions of skeletal muscle in the context of long-term HUD. Exercise also produced antidepressant effects. Our data suggest that the effects of AICAR and exercise on DlR may further increase our understanding on the link between depression and diabetes. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据