期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 155, 期 -, 页码 42-48出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2013.10.021
关键词
Cortical thickness; Cortical volume; Subcortical volume; Depression; First episode; Medication-naive
资金
- Korea Healthcare Technology R&D Project, Ministry for Health, Welfare, & Family Affairs, Republic of Korea [A100531]
- Korea Health Promotion Institute [A100531] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background: The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and white matter integrity between first episode, medication-naive MDD patients and healthy controls. Methods: Subjects with their first episode of MDD whose illness duration had not exceeded 6 months (n=20) were enrolled in this study and were compared to age-, sex-, and education level marched healthy controls (n=22). All participants were subjected to T1-weighted structural magnetic resonance imaging (MRl). We used an automated procedure of FreeSurfer and Tract-based spatial statistics (TBSS) to analyze differences in cortical thickness, cortical and subcortical volume, and white matter integrity between two groups. Results: The patients with first episode MDD exhibited significantly reduced cortical volume in the caudal anterior cingulate gyrus (P <0.0015) compared to healthy controls. We also observed altered white matter integrity in the body of the corpus callosum (P <0.01), reduced cortical volume of the caudal middle frontal gyrus and medial orbitofrontal gyrus, and enlarged hippocampal volume in the first episode MDD patients. Limitations: We relied on a relatively small sample size and cortical volume reduction in several brain regions was not replicated in the analysis of cortical thickness. Conclusions: Using multimodal imaging analyses on medication-naive first episode MDD patients, we demonstrated fundamental structural alteration of brain gray and white matter, such as reduced cortical volume of the caudal ACC and white matter integrity in the body of the corpus callosum. (C) 2013 Elsevier B.V. All rights reserved
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