期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 152, 期 -, 页码 288-294出版社
ELSEVIER
DOI: 10.1016/j.jad.2013.09.027
关键词
Facial emotion recognition; Executive function; Bipolar disorder; Mania; Depression; Euthymia
资金
- Sao Paulo Research Foundation (FAPESP)
- [2010/16934-4]
Introduction: The ability to recognize facial emotions is altered in patients with Bipolar Disorder (BD) during mood episodes and even in euthymia, while cognitive functioning is similarly impaired. This recognition is considered a fundamental skill for successful social interaction. However, it is unclear whether the ability to recognize facial emotions is correlated with the cognitive deficits observed in BD. Objective: The objective of this study was to evaluate Facial Emotion Recognition (PER) and its correlation with executive function (FE) in BD I patients during mania, depression and euthymia compared to healthy controls. Material and methods: A total of 110 patients with BD I, 18-40 years old were included (41 in manic episode; 31 in depressive episode and 38 euthymic). Patients were assessed for FER and EF (Wisconsin card sorting test - WCST), along with 96 healthy volunteers (18-40 years old) recruited from the University of Sao Paulo. Results: The results showed that BD l patients had lower FER performance compared to controls on fear subtests, happiness, the surprise Lest, and E'ER total scores. Moreover, BD l manic patients showed poorer performance for EF compared to controls. Six out of the seven variables of the WCST correlated with E'ER in both healthy controls and BD euthymic subjects but not in BD patients during mood episodes. Conclusion: Cognitive deficits and difficulties recognizing facial emotions are present in all mood episodes in BD l patients, even during remission. Although FER is not considered a cognitive domain, these results suggest that, along with EF, it has a complementary function. Hence, further studies should investigate this issue in larger samples and verify whether these similarities also occur at a neurobiological level. (C) 2013 Elsevier B.V. All rights reserved.
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