期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 148, 期 1, 页码 136-140出版社
ELSEVIER
DOI: 10.1016/j.jad.2012.10.036
关键词
Antidepressant agents; Biological markers; Cytokines; Neuroinflammation; Psychoneuroimmunology; Endophenotype
资金
- UK Medical Research Council
- NARSAD
- South London and Maudsley NHS Foundation Trust & Institute of Psychiatry NIHR Biomedical Research Centre for Mental Health
- Commission of European Communities 7th Framework Programme Collaborative Project [22963]
- ECNP Young Investigator Award
- MRC [G108/603, MR/J002739/1] Funding Source: UKRI
- Medical Research Council [MR/J002739/1, G108/603] Funding Source: researchfish
Despite the evidence of an association between depression and increased inflammatory markers, still little is known in relation to the most severe cases of the disorder i.e., those who fail to respond to antidepressants. We have assessed the cytokine profile and cortisol levels in 21 healthy controls (HC) and 19 medicated patients with depression with treatment-resistance (TRD) moderately ill. As an initial exploratory analysis, we have also related cytokine profile to the patient's clinical treatment outcome after an inpatient admission. Cytokine profile was measured in the serum by the Cytokine Array I kit (Randox). Plasma cortisol was carried out using a commercially available for the IMMULITE system. When compared to healthy controls, depressed patients had higher levels of cortisol, IL-6, IL-10, but lower levels of IL-4 and VEGF. Our exploratory analysis showed subjects who did not go on to respond to the inpatient admission treatment package had lower levels of MCP-1, and a trend toward lower levels of VEGF. Taking together, these data suggest that lack of clinical therapeutic benefit of antidepressants is associated with overall activation of the inflammatory system. (C) 2012 Elsevier BY. All rights reserved.
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