期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 148, 期 2-3, 页码 256-264出版社
ELSEVIER
DOI: 10.1016/j.jad.2012.12.004
关键词
Mood disorder; Comorbidity; Quick Inventory of Depression; Symptomatology-16 items; Pattern; Sensitivity and specificity; Predictive value
资金
- Astrazeneca
- Brain and Behavior Research Foundation
- Cleveland Foundation
- Abbott
- Bristol-Myers Squibb/Otsuka
- Cephalon
- Dainippon Sumitomo
- Forest
- France Foundation
- GlaxoSmithKline
- Janssen
- Johnson and Johnson
- Lilly
- Lundbeck
- Merck
- Neurosearch
- OrthoMcNeil
- Pfizer
- Repligen
- Sanofi
- Schering-Plough
- Servier
- Solvay
- Synosia
- Supernus Pharmaceuticals
- Takeda
- Wyeth
Background: Axis I comorbidity in mood disorders was common in epidemiological studies. This study was designed to investigate the prevalence, pattern, and number of Axis I comorbidities and the role of the Quick Inventory of Depression Symptomatology - 16 items-Self-Report (QIDS-16-SR) in predicting the number of comorbidities in major depressive disorder (MDD) or bipolar disorder (BPD). Methods: Baseline data from the first 300 routine clinical outpatients diagnosed with the Mini International Neuropsychiatric Interview Systematic-Treatment-Enhancement - Program for BPD version 5.0.0 were used. Baseline severity was measured with QIDS-16-SR and Clinical Global Impression-Severity (CGI-S). Results: Of 113 patients with MDD and 166 with BPD, the prevalence of any current anxiety disorder (AD), substance use disorder (SUD), and attention deficit hyperactivity disorder (ADHD) was 76% versus 74%, 14% versus 29%, and 8% versus 21%, respectively. The most common patterns of current comorbidity were MDD+AD (58.4%) for MDD, and BPD+AD (39.8%) and BPD+AD+SUD (11.4%) for BPD. More than 80% patients with MDD or BPD had >= 1 current comorbid disorder. About 20% patients with BPD and 10% with MDD had >= 4 other disorders. The number of comorbidities was positively associated with baseline severity and suicidal ideation in both MDD and BPD. A QIDS-16-SR of 10 had a positive predictive value of >= 90% in predicting >= 1 comorbidity in MDD and BPD. Limitations: The sample was modest and from a tertiary medical center. Conclusion: A thorough diagnostic assessment for Axis I comorbidity should be included in all patients with mood disorders, especially when a QIDS-16-SR of >= 10 points. (c) 2012 Elsevier B.V. All rights reserved.
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