期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 136, 期 3, 页码 909-917出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2011.09.010
关键词
Chronic fatigue syndrome; Inflammation; Cytokines; Depression; Oxidative stress; Leaky gut
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by a) systemic IgA/IgM responses against the lipopolysaccharides (LPS) of commensal bacteria; b) inflammation, e.g. increased plasma interleukin-(IL)1 and tumor necrosis factor (TNF)alpha; and c) activation of cell-mediated immunity (CMI), as demonstrated by increased neopterin. Methods: To study the relationships between the IgA/IgM responses to the LPS of microbiota, inflammation, CMI and the symptoms of ME/CFS we measured the IgA/IgM responses to the LPS of 6 different enterobacteria, serum IL-1, TNF alpha, neopterin, and elastase in 128 patients with ME/CFS and chronic fatigue (CF). Severity of symptoms was assessed by the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale. Results: Serum IL-1, TNF alpha, neopterin and elastase are significantly higher in patients with ME/CFS than in CF patients. There are significant and positive associations between the IgA responses to LPS and serum IL-1. TNF alpha, neopterin and elastase. Patients with an abnormally high IgA response show increased serum IL-1, TNF alpha and neopterin levels, and higher ratings on irritable bowel syndrome (IBS) than subjects with a normal IgA response. Serum IL-1, TNF alpha and neopterin are significantly related to fatigue, a flu-like malaise, autonomic symptoms, neurocognitive disorders, sadness and irritability. Conclusions: The findings show that increased IgA responses to commensal bacteria in ME/CFS are associated with inflammation and CMI activation, which are associated with symptom severity. It is concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients. (C) 2011 Elsevier B.V. All rights reserved.
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