期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 139, 期 3, 页码 264-272出版社
ELSEVIER
DOI: 10.1016/j.jad.2012.01.038
关键词
Bipolar disorder; Social rhythms; Circadian rhythms; Life events
资金
- National Institute of Mental Health [MH 52617, MH 77908, MH 52662]
Objectives: To examine the presence of an underlying social rhythm sensitivity in individuals with bipolar spectrum disorders. Methods: The present study examined the impact of life events on sleep loss and social rhythm disruption in 184 individuals with bipolar spectrum disorders (BSD) compared to 197 demographically similar normal controls (NC) drawn from the Longitudinal Investigation of Bipolar Spectrum Disorders (LIBS) project. Life events data were obtained at three time points, each spaced four months apart, and included information on the intensity of the event (high or low), valence (negative or positive), and levels of sleep loss and social rhythm disruption brought about the event. We hypothesized that BSD participants would exhibit higher levels of social rhythm disruption and sleep loss than normal controls as a consequence of the same life events. Results: BSD participants experienced significantly more social rhythm disruption and sleep loss following all classes of life events. Limitations: The cross-sectional design of this study limits the strength of the conclusions that can be drawn, primarily cause and effect relationships between social rhythms and symptoms. Conclusions: Findings support the presence of an underlying social rhythm sensitivity in individuals with bipolar spectrum disorders. An additive effect of sleep loss and social rhythm disruption may contribute to subsequent mood symptomatology. Results from this study may inform early psychosocial interventions for at-risk individuals. (C) 2012 Elsevier B.V. All rights reserved.
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