期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 134, 期 1-3, 页码 483-487出版社
ELSEVIER
DOI: 10.1016/j.jad.2011.05.057
关键词
Depression; Structural magnetic resonance imaging; Hippocampus; Meta-analysis
资金
- Medical Research Council
- National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health
- Medical Research Council [G90/96, G9817803B] Funding Source: researchfish
- MRC [G90/96, G0802594] Funding Source: UKRI
Background: Reduced hippocampal volume has been consistently observed in major depressive disorder. Hippocampal volume loss is particularly evident in patients with recurrent and chronic depression. However, the reports in first episode depression have been mixed. Methods: We performed a random effects meta-analysis to establish whether hippocampal atrophy exists from disease onset. We included magnetic resonance imaging studies of hippocampal volume in patients with first episode major depressive disorder and matched healthy controls. Results: A total of 7 studies met our inclusion and exclusion criteria, representing independent observations in a total sample of 191 patients and 282 healthy controls. The cumulative analysis revealed hippocampal volume loss in patients with first episode depression relative to controls in both the left (standardised mean difference, SMD = -0.41, 95% Confidence Interval: [-0.78; -0.03], z = -2.14, p = 0.0321) and right (SMD = -0.53[-0.98; -0.09], z = -2.38, p = 0.0173) hippocampi. The average volume reduction was -4.0% in the left and -4.5% in the right hippocampus. Conclusions: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression. (C) 2011 Elsevier B.V. All rights reserved.
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