期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 77
卷 77, 期 -, 页码 347-362出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021014-071821
关键词
pH sensing; bicarbonate; soluble adenylyl cyclase; proton-sensing GPCRs; acid-sensing ion channels
类别
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD059913] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062328] Funding Source: NIH RePORTER
- NICHD NIH HHS [HD059913] Funding Source: Medline
- NIGMS NIH HHS [GM62328] Funding Source: Medline
Acid-base homeostasis is essential for life. The macromolecules upon which living organisms depend are sensitive to pH changes, and physiological systems use the equilibrium between carbon dioxide, bicarbonate, and protons to buffer their pH. Biological processes and environmental insults are constantly challenging an organism's pH; therefore, to maintain a consistent and proper pH, organisms need sensors that measure pH and that elicit appropriate responses. Mammals use multiple sensors for measuring both intracellular and extracellular pH, and although some mammalian pH sensors directly measure protons, it has recently become apparent that many pH-sensing systems measure pH via bicarbonate-sensing soluble adenylyl cyclase.
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