期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 124, 期 3, 页码 256-261出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2009.12.002
关键词
Bipolar disorder; Hypothalamic-pituitary-adrenal axis; Pituitary gland; Magnetic resonance imaging; Relatives
资金
- Japanese Society for the Promotion of Science [19591346]
- Ministry of Health and Welfare, Japan [17-2, 18-6]
- Pfizer
- NHMRC
- NARSAD
- National Institute for Health Research (NIHR)
- Biomedical Research Centre for Mental Health
- Grants-in-Aid for Scientific Research [19591346] Funding Source: KAKEN
Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been reported in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have yielded inconsistent findings. In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown. Method: We used MRI to investigate the pituitary volume in 29 remitted patients with BD, 49 of their first-degree relatives (of whom 15 had a diagnosis of Major Depressive Disorder), and 52 age- and gender-matched healthy controls. Results: BD patients had a significantly larger pituitary volume compared with their relatives and healthy controls. Pituitary volume did not differ between controls and healthy relatives or relatives diagnosed with major depression. Limitations: Direct measures of HPA function (i.e., hormonal levels) were not available. Conclusions: These findings suggest that enlarged pituitary volume is associated with disease expression but not genetic susceptibility to BD. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据