期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 117, 期 1-2, 页码 1-17出版社
ELSEVIER
DOI: 10.1016/j.jad.2008.11.021
关键词
Depression; Imaging; Brain; Morphology; Hippocampus; Amygdala; Cingulate
资金
- Australian Research Council [DP0557663]
- NHMRC Program Grant [DP0557663, 350241]
- Colonial Foundation
- J.N. Peters Fellowship
- NHMRC CJ Martin Fellowship [454797]
- Faculty of Psychology
- The University of Bologna
- international Postgraduate Research Scholarship
- Melbourne International Research Scholarship
- Australian Research Council [DP0557663] Funding Source: Australian Research Council
Background: While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear. Aims: To review recent structural magnetic resonance imaging (MRI) research findings in MDD while considering the potential influence of key clinical and demographic variables. Method: A selective review of all T1-weighted structural MRI studies published between 2000 and 2007 in adult samples of MDD patients. Results: Volumetric reductions of the hippocampus, basal ganglia and OFC and SGPFC are consistently found in MDD patients, with more persistent forms of MDD (e.g., Multiple episodes or repeated relapses, longer illness duration) being associated with greater impact on regional brain volumes. Gender, medication, stage of illness, and family history all affect the nature of the findings in a regionally specific manner. Limitations: Overall, differences between the samples in factors such as illness severity, medication, gender and family history of mental illness makes difficult to identify their confounding effects on the observed neuroanatomical changes. Also, the tracing protocols used for particular brain regions were different amongst the reviewed studies, making difficult to compare their findings. Conclusions: The data support the notion that MDD involves pathological alterations of limbic and cortical structures, and that they are generally more apparent in patients with more severe or persistent forms of the illness. (C) 2009 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据