期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 117, 期 3, 页码 212-216出版社
ELSEVIER
DOI: 10.1016/j.jad.2009.01.009
关键词
Intensity dependence Auditory Evoked; Potentials (IDAEP); Melancholia; Major depression
资金
- NHMRC Practitioner Fellowship
Background: Major Depressive Disorder is widely recognised to be a heterogeneous syndrome with numerous depressive phenotypes, one of which is melancholic depression. Patients with melancholic depression exhibit treatment responses and outcomes that differ from patients with non-melancholic depression. The current study aimed to assess whether differences existed between melancholic and non-melancholic subtypes of depression, as measured by the event related potential, intensity dependence of the auditory evoked potential (IDAEP). Methods: IDAEP was assessed in 14 melancholic and 13 non-melancholic depressed subjects and 14 controls. Results: The melancholic patients had a significantly shallower IDAEP slope than the nonmelancholic patients not explained by depression severity or age. Limitations: Antidepressants were taken by all patients in this study and the effect of continual use of these drugs on the IDAEP slopes has yet to be confirmed. Conclusions: These results provide support for neurobiological differences between melancholic and non-melancholic depressive subtypes. Melancholic depression may be characterized by ongoing over function of the serotonin system in spite of medication treatment. (C) 2009 Elsevier B.V. All rights reserved.
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