期刊
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
卷 22, 期 4, 页码 341-353出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jamp.2008.0696
关键词
airway occlusion; liquid aerosols; meniscus breakup
资金
- Technion
- National Heart, Lung, and Blood Institute [HL054885, HL070542, HL074022]
Background: Droplets exhaled during normal breathing and not associated with coughing may pose hazardous agents to infective diseases dissemination. The objective is to explore the physical mechanism, which may lead to droplets formation. Methods: We hypothesize that liquid menisci occlusions, which may form inside small airways, travel along the airway, may lose mass and finally disintegrate into small droplets. This hypothesis was numerically investigated applying physiologically plausible values of the phenomenological coefficients and geometrical conformations. Results: We show that three important dimensionless parameters control the motion and disintegration of menisci: the dimensionless mucus layer thickness, the dimensionless menisci initial thickness (all scaled by the airway radius), and the capillary number. Menisci traveling within airways may either remain at equilibrium or diminish or increase in size. Menisci that diminish in size may collapse into the mucus layer; form a large droplet that contains most of the menisci mass before disintegration; or form a larger number of small droplets (we show the forming of three or four droplets in a single occluded airway). Conclusions: A critical capillary number for menisci at equilibrium could be defined. It was shown that menisci tend to diminish in size as the capillary number increases above the critical value, and a number of small droplets may be formed during normal breathing.
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