期刊
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
卷 763, 期 -, 页码 246-257出版社
ELSEVIER
DOI: 10.1016/j.mrrev.2014.11.004
关键词
Infectious diseases; Inflammatory response; DNA damage; DNA repair; Innate immunity; Adaptive immunity
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq-Brazil)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES-Brazil)
In recent years, the understanding of how DNA repair contributes to the development of innate and acquired immunity has emerged. The DNA damage incurred during the inflammatory response triggers the activation of DNA repair pathways, which are required for host-cell survival. Here, we reviewed current understanding of the mechanism by which DNA repair contributes to protection against the oxidized DNA damage generated during infectious and inflammatory diseases and its involvement in innate and adaptive immunity. We discussed the functional role of DNA repair enzymes in the immune activation and the relevance of these processes to: transcriptional regulation of cytokines and other genes involved in the inflammatory response; V(D)J recombination; class-switch recombination (CSR); and somatic hypermutation (SHM). These three last processes of DNA damage repair are required for effective humoral adaptive immunity, creating genetic diversity in developing T and B cells. Furthermore, viral replication is also dependent on host DNA repair mechanisms. Therefore, the elucidation of the pathways of DNA damage and its repair that activate innate and adaptive immunity will be important for a better understanding of the immune and inflammatory disorders and developing new therapeutic interventions for treatment of these diseases and for improving their outcome. (C) 2014 Elsevier B.V. All rights reserved.
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