期刊
MUSCLE & NERVE
卷 52, 期 4, 页码 649-657出版社
WILEY
DOI: 10.1002/mus.24576
关键词
Botox (R); denervation; fiber type; muscle physiology; neurotoxin
资金
- Department of Veterans Affairs [RX000670]
- NIH [R24HD050837, AR057013]
- Allergan, Inc
Introduction: Botulinum toxin is frequently administered serially to maintain therapeutic muscle paralysis, but the effect of repeated doses on muscle function are largely unknown. This study characterized the muscle response to 2 onabotulinum toxin (BoNT) injections separated by 3 months. Methods: Animal subjects received a single toxin injection (n = 8), 2 BoNT injections separated by 3 months (n = 14), or 1 BoNT and 1 saline injection separated by 3 months (n = 8). Results: The functional effect of 2 serial injections was exponentially greater than the effect of a single injection. While both groups treated with a single BoNT injection had decreased torque in the injected leg by approximately 50% relative to contralateral legs, the double BoNT injected group had decreased torque by over 95% relative to the preinjection level. Both single and double BoNT injections produced clear signs of fiber-type grouping. Conclusions: These experiments demonstrate a disproportionately greater effect of repeated BoNT injections.
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