4.4 Article

Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both genders

期刊

MUSCLE & NERVE
卷 52, 期 5, 页码 788-794

出版社

WILEY-BLACKWELL
DOI: 10.1002/mus.24604

关键词

cardiac muscle; function; mdx mouse; skeletal muscle; voluntary activity

资金

  1. Universite Pierre et Marie Curie
  2. CNRS
  3. INSERM
  4. University Paris Descartes
  5. Association Francaise contre les Myopathies

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Introduction: The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc-DMDmdx/J) mice on skeletal and cardiac muscle function have not been studied extensively. Methods: We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction-induced injury, and left ventricular function in mdx mice. Results: We found that voluntary wheel running did not worsen the deficit in force-generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers. Conclusion: These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender. Muscle Nerve52: 788-794, 2015

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