期刊
ANNUAL REVIEW OF NEUROSCIENCE, VOL 38
卷 38, 期 -, 页码 269-289出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-071714-033936
关键词
structural model; systematic cortical variation; cortical development; emotions; schizophrenia; autism
资金
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke [R01NS024760]
- National Institute of Mental Health [R01MH057414]
- National Science Foundation [BNS 8315411]
- National Science Foundation [Center of Excellence for Learning in Education, Science and Technology (CELEST) NSF] [SBE-0354378]
How is the vast brain communication system organized? A structural model relates connections to laminar differences between linked areas. The model is based on the principle of systematic structural variation in the cortex, extending from the simplest limbic cortices to eulaminate areas with elaborate lamination. The model accounts for laminar patterns and for the strength and topography of connections between nearby or distant cortices and subcortical structures, exemplified quantitatively for the principal and special prefrontal connections. Widespread connections of limbic areas and focal connections of eulaminate areas yield a broad range of circuit patterns for diverse functions. These diverse pathways innervate excitatory and functionally distinct inhibitory neurons, providing the basis for differential recruitment of areas for flexible behavior. Systematic structural variation likely emerges by timing differences in the development of distinct areas and has important implications for altered connections in diseases of developmental origin.
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