期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 69
卷 69, 期 -, 页码 229-245出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-091014-104432
关键词
heme; oxidative stress; manganese; transcriptional control; iron export
类别
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM099667] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM099667] Funding Source: Medline
Iron is an essential nutrient, but it can also be toxic. Therefore, iron homeostasis must be strictly regulated. Transcriptional control of iron-dependent gene expression in the rhizobia and other taxa of the Alphaproteobacteria is fundamentally different from the Fur paradigm in Escherichia oil and other model systems. Rather than sense iron directly, the rhizobia employ the iron response regulator (Irr) to monitor and respond to the status of an iron-dependent process, namely, heme biosynthesis. This novel control mechanism allows iron homeostasis to be integrated with other cellular processes, and it permits differential control of iron regulon genes in a manner not readily achieved by Fur. Moreover, studies of Irr have defined a role for heme in conditional protein stability that has been subsequently described in cukaryotes. Finally, Irr-mediated control of iron metabolism may reflect a cellular strategy that accommodates a greater reliance on manganese.
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