期刊
ANNUAL REVIEW OF MEDICINE, VOL 66
卷 66, 期 -, 页码 311-328出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-051113-024537
关键词
cytokine; autoimmunity; immunodeficiency; cancer; kinase inhibitors
资金
- Intramural NIH HHS [Z99 AR999999] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [ZIAAR041167, ZIAAR041159, ZIAAR041106, ZICAR041181] Funding Source: NIH RePORTER
The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a fundamental paradigm for how cells sense environmental cues and interpret these signals to regulate cell growth and differentiation. Genetic mutations and polymorphisms are functionally relevant to a variety of human diseases, especially cancer and immune-related conditions. The clinical relevance of the pathway has been confirmed by the emergence of a new class of therapeutics that targets JAKs.
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