期刊
ANNUAL REVIEW OF IMMUNOLOGY VOL 33
卷 33, 期 -, 页码 787-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-032414-112326
关键词
innate immunity; adaptive immunity; autoimmunity; immunodeficiency; malignancy; immunotherapy
类别
资金
- MRC [G0801936] Funding Source: UKRI
- Cancer Research UK [15032] Funding Source: researchfish
- Cancer Research UK [13174] Funding Source: Medline
- Medical Research Council [G0801936] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an asymptomatic infection of the B lymphoid system. However, many circumstances disturb the delicate EBV-host balance and cause the virus to display its pathogenic potential. Thus, primary infection in adolescence can manifest as infectious mononucleosis (IM), as a fatal illness that magnifies the inu-nunopathology of PM in boys with the X-linked lymphoproliferative disease trait, and as a chronic active disease leading to life-threatening hemophagocytosis in rare cases of T or natural killer (NK) cell infection. Patients with primary immunodeficiencies affecting the NK and/or T cell systems, as well as inu-nunosuppressed transplant recipients, handle EBV infections poorly, and many are at increased risk of virus-driven B-It mphoproliferative disease. By contrast, a range of other EBV-positive malignancies of lymphoid or epithelial origin arise in individuals with seemingly intact immune systems through mechanisms that remain to be understood.
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