期刊
ANNUAL REVIEW OF IMMUNOLOGY VOL 33
卷 33, 期 -, 页码 355-391出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-032414-112103
关键词
TYRO3; AXL MERTK; GAS6; PROS1
类别
资金
- NATIONAL CANCER INSTITUTE [P50CA095060] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI089824] Funding Source: NIH RePORTER
- NCI NIH HHS [P50 CA095060, CA95060] Funding Source: Medline
- NIAID NIH HHS [R01AI089824, R01 AI089824] Funding Source: Medline
The TAM receptor tyrosine kinases (RTKs)-TRO3, AXL, and MERTK together with their cognate agonists GAS6 and PROS1 play an essential role us the resolution of inllanilnation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.
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