期刊
ANNUAL REVIEW OF IMMUNOLOGY VOL 33
卷 33, 期 -, 页码 201-225出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-032713-120218
关键词
mucosal immunity; innate lymphoid cells; effector mechanisms
类别
资金
- Medical Research Council Funding Source: Medline
- Wellcome Trust [WT100290MA, 100290] Funding Source: Medline
Helminth parasites are a highly successful group of pathogens that challenge the immune system in a manner distinct from rapidly replicating infectious agents. Of this group, roundworms (nematodes) that dwell in the intestines of humans and other animals are prevalent worldwide. Currently, more than one billion people are infected by at least one species, often for extended periods of time. Thus, host-protective immunity is rarely complete. The reasons for this are complex, but laboratory investigation of tractable model systems in which protective immunity is effective has provided a mechanistic understanding of resistance that is characterized almost universally by a type 2/T helper 2 response. Greater understanding of the mechanisms of susceptibility has also provided the basis for defining host immunoregulation and parasite-evasion strategies, helping place in context the changing patterns of immunological disease observed worldwide.
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