期刊
MOVEMENT DISORDERS
卷 30, 期 14, 页码 1961-1964出版社
WILEY
DOI: 10.1002/mds.26457
关键词
Huntington's disease; microRNA; miRNA; blood; biomarker
资金
- Jerry McDonald HD Research Fund
- US National Institutes of Health Epigenetic Markers in Huntington's disease Brain [R01 NS073947]
Background: Biomarkers for Huntington's disease progression could accelerate therapeutic developments and improve patient care. Brain microRNAs relating to clinical features of Huntington's disease may represent a potential Huntington's disease biomarker in blood. Objective: This study was undertaken to examine candidate microRNAs in plasma to determine whether changes observed in HD brains are detectable in peripheral samples. Methods: Four microRNAs from 26 manifest Huntington's disease, four asymptomatic Huntington's disease gene carriers, and eight controls were quantified in plasma using reverse transcription quantitative polymerase chain reaction. Linear regression was used to assess microRNA levels across control, asymptomatic gene carriers, and manifest patients. Results: miR-10b-5p (P = 0.0068) and miR-486-5p (P = 0.044) were elevated in Huntington's disease plasma. miR-10b-5p was decreased in asymptomatic gene carriers as compared with patients with Huntington's disease (P = 0.049), but no difference between asymptomatic gene carriers and healthy controls was observed (P = 0.24). Conclusions: These findings suggest that microRNA changes observed in Huntington's disease brain may be detectable in plasma and have potential clinical utility. (C) 2015 International Parkinson and Movement Disorder Society
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