期刊
MOVEMENT DISORDERS
卷 30, 期 9, 页码 1248-1258出版社
WILEY
DOI: 10.1002/mds.26294
关键词
force; functional MRI; progressive supranuclear palsy; Parkinson's disease; motor circuits
资金
- National Institutes of Health [R01 NS052318, R01 NS075012]
- National Parkinson Foundation Center of Excellence
- Bachmann-Strauss Foundation
- Wright/Fall/Simons Fund
Background: The basal ganglia-thalamocortical and cerebello-thalamo-cortical circuits are important for motor control. Whether their functioning is affected in a similar or different way by progressive supranuclear palsy (PSP) and Parkinson's disease (PD) is not clear. Methods: A functional magnetic resonance imaging (fMRI) force production paradigm and voxel-based morphometry were used to assess differences in brain activity and macrostructural volumes between PSP, PD, and healthy age-matched controls. Results: We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD. In PSP the frontal regions are underactive, whereas the posterior parietal and occipital regions are overactive as compared with controls and PD. Furthermore, lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD, whereas Crus I and lobule IX are hyperactive in PSP only. Reductions in gray and white matter volume are specific to PSR Finally, the functional status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSR Conclusions: PSP and PD share hypoactivity of the basal ganglia, motor cortex, and anterior cerebellum. These patients also display a unique pattern, such that anterior regions of the cortex are hypoactive and posterior regions of the cortex and cerebellum are hyperactive. Together, these findings suggest that specific structures within the basal ganglia, cortex, and cerebellum are affected differently in PSP relative to PD. (C) 2015 International Parkinson and Movement Disorder Society
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