期刊
JOINT BONE SPINE
卷 81, 期 4, 页码 337-341出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.jbspin.2013.11.006
关键词
Anti-neutrophil cytoplasm; antibody-associated vasculitis; Meta-analysis; Mycophenolic acid; Leflunomide; Methotrexate; Azathioprine
类别
资金
- Alberta Innovates Health Solutions Clinical Fellowship
- Vasculitis Clinical Research Consortium
- Toronto General Hospital/Toronto Western Hospital Foundation/University Health Network, Toronto, ON, Canada
Objective: To determine the comparative efficacy of non-biologic treatments for remission maintenance in ANCA-associated vasculitis. Methods: We identified all randomized trials comparing leflunomide, azathioprine, methotrexate or mycophenolate mofetil in adult patients with granulomatosis with polyangiitis or microscopic polyangiitis. Relapse-free survival was compared through hazard ratios (HR) using a Bayesian fixed-effects network meta-analysis. Multiple sensitivity analyses were performed to explore biases identified in one trial using original trial data. Results: Three trials were available (leflunomide-methotrexate, methotrexate- azathioprine, azathioprine-mycophenolate). Mycophenolate was inferior to all treatments, although the 95% credible interval (CrI) of the HR relative to methotrexate crossed 1. Leflunomide was superior to azathioprine (HR 0.43 [95% CrI: 0.14-1.3]) and methotrexate (HR 0.47 [95% CrI: 0.18-1.2]), although the 95% CrI also crossed 1. There was a 90% probability that leflunomide was the best treatment. After down weighting the effect of leflunomide vs. methotrexate for early trial termination and slow MTX dose escalation, there remained a 55% probability leflunomide was best. Conclusion: Based on indirect evidence, leflunomide is effective in maintaining remission in granulomatosis with polyangiitis or microscopic polyangiitis relative to other non-biologic treatments. Further randomized trials of leflunomide are needed for confirmation. (C) 2013 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
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