期刊
ANNUAL REVIEW OF ENTOMOLOGY, VOL 60
卷 60, 期 -, 页码 435-452出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-ento-010814-020803
关键词
environment; plasticity; gene body methylation; transcription; alternative splicing
类别
资金
- Howard Hughes Medical Institute [2009005] Funding Source: Medline
In eusocial insects, genetically identical individuals can exhibit striking differences in behavior and longevity. The molecular basis of such phenotypic plasticity is of great interest to the scientific community. DNA methylation, as well as other epigenetic signals, plays an important role in modulating gene expression and can therefore establish, sustain, and alter organism-level phenotypes, including behavior and life span. Unlike DNA methylation in mammals, DNA methylation in insects, including eusocial insects, is enriched in gene bodies of actively expressed genes. Recent investigations have revealed the important role of gene body methylation in regulating gene expression in response to intrinsic and environmental factors. In this review, we summarize recent advances in DNA methylation research and discuss its significance in our understanding of the epigenetic underpinnings of behavior and longevity.
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