期刊
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 11
卷 11, 期 -, 页码 309-330出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-clinpsy-032814-112814
关键词
chronic traumatic encephalopathy; concussion; traumatic brain injury; neurodegenerative disorders; football; history
资金
- NIA NIH HHS [P30 AG13846] Funding Source: Medline
- NINDS NIH HHS [R01 NS078337] Funding Source: Medline
- CSRD VA [I01 CX001038] Funding Source: Medline
- VA [1080103, 5I01CX001038-04] Funding Source: Federal RePORTER
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is most often identified in postmortem autopsies of individuals exposed to repetitive head impacts, such as boxers and football players. The neuropathology of CTE is characterized by the accumulation of hyperphosphorylated tau protein in a pattern that is unique from that of other neurodegenerative diseases, including Alzheimer's disease. The clinical features of CTE are often progressive, leading to dramatic changes in mood, behavior, and cognition, frequently resulting in debilitating dementia. In some cases, motor features, including parkinsonism, can also be present. In this review, the historical origins of CTE are revealed and an overview of the current state of knowledge of CTE is provided, including the neuropathology, clinical features, proposed clinical and pathological diagnostic criteria, potential in vivo biomarkers, known risk factors, and treatment options.
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