期刊
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
卷 9, 期 2, 页码 215-224出版社
SPRINGER
DOI: 10.1007/s10162-008-0114-2
关键词
ankle link; auditory system; basal link; kinociliary link; kinocilium; stereocilium; tip link; vestibular system
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCRR NIH HHS [P20 RR020647, RR020647] Funding Source: Medline
- NIBIB NIH HHS [EB4873, R01 EB004873] Funding Source: Medline
- NIDCD NIH HHS [DC07680, DC00241, R01 DC000241-27, F32 DC000241, R55 DC007680, R01 DC000241] Funding Source: Medline
- NIGMS NIH HHS [GM074258, R01 GM064473, GM073087, R01 GM073087, GM064473, R01 GM074258] Funding Source: Medline
The senses of hearing and balance rest upon mechanoelectrical transduction by the hair bundles of hair cells in the inner ear. Located at the apical cellular surface, each hair bundle comprises several tens of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. Using electron-microscopic tomography of bullfrog saccular sensory epithelia, we examined the three-dimensional structures of basal links, kinociliary links, and tip links. We observed significant differences in the appearances and dimensions of these three structures and found two distinct populations of tip links suggestive of the involvement of different proteins, splice variants, or protein-protein interactions. We noted auxiliary links connecting the upper portions of tip links to the taller stereocilia. Tip links and auxiliary links show a tendency to adopt a globular conformation when disconnected from the membrane surface.
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