期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31
卷 31, 期 -, 页码 83-108出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100814-125438
关键词
Lis1; Nudel/NudE; dvnactin; microtubule; transport; cytoskeleton
资金
- NIGMS NIH HHS [R01 GM100947, R01 GM107214, R01GM107214, R01GM100947] Funding Source: Medline
Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth of new structural, mechanistic, and cell biological data is shedding light on how this complicated minus-end-directed, microtubule-based motor works. Cytoplasmic dynein-1 performs a wide array of functions in most eukaryotes, both in interphase, in which it transports organelles, proteins, mRNAs, and viruses, and in mitosis and meiosis. Mutations in dynein or its regulators are linked to neurodevelopmental and neurodegenerative diseases. Here, we begin by providing a synthesis of recent data to describe the current model of dynein's mechanochemical cycle. Next, we discuss regulators of dynein, with particular focus on those that directly interact with the motor to modulate its recruitment to microtubules, initiate cargo transport, or activate minus-end-directed motility.
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