期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31
卷 31, 期 -, 页码 699-720出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100814-125353
关键词
neocortex; identity; projection neurons; interneurons; cortical networks; myclination profile
资金
- NINDS NIH HHS [R01 NS062849] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS062849] Funding Source: NIH RePORTER
The neocortex is the part of the brain responsible for execution of higher-order brain functions, including cognition, sensory perception, and sophisticated motor control. During evolution, the neocortex has developed an unparalleled neuronal diversity, which still remains partly unclassified and unmapped at the functional level. Here, we broadly review the structural blueprint of the neocortex and discuss the current classification of its neuronal diversity. We then cover the principles and mechanisms that build neuronal diversity during cortical development and consider the impact of neuronal class-specific identity in shaping cortical connectivity and function.
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