期刊
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
卷 39, 期 11, 页码 756-766出版社
OXFORD UNIV PRESS
DOI: 10.1093/jjco/hyp074
关键词
tumor delivery; angiotensin-induced hypertension; SMANCS; intra-arterial infusion; metastatic liver cancer
类别
资金
- The Ministry of Education, Culture, Sports, Science, and Technology, Japan [20015045]
- Takeda Science Foundation [2003-2010]
- Grants-in-Aid for Scientific Research [20015045] Funding Source: KAKEN
The purpose of this study is to evaluate the improved method of arterial infusion therapy of SMANCS (SX) with lipiodol under the angiotensin-induced hypertensive state for various difficult-to-treat solid tumors. Most patients were unresectable with no other therapeutic options, recurrence after resection, or patients do not respond to common treatments. The new method utilizes angiotensin II (AT) to induce hypertension (e.g. similar to 15-30 mmHg above norm) for 15-20 min. This method was successfully applied to metastatic liver cancer, cholangiocarcinoma, massive renal cell carcinoma, pancreatic and other abdominal solid cancers. This AT-induced hypertension resulted in remarkably enhanced tumor delivery accompanied by improved therapeutic response, and a shorter time to achieve 50% regression of tumor size with least toxicity. We demonstrated clinically herein improved therapy for various advanced solid tumors with SX by elevating the tumor blood flow selectively. This is the first clinical proof that modulations of vascular pathophysiology can uniquely accomplish enhanced tumor selective delivery of polymeric drugs and thus yielded better clinical outcome.
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