期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84
卷 84, 期 -, 页码 131-164出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060614-034115
关键词
chromatin; intermediate filament; lamins; laminopathies; nuclear envelope; nuclear mechanics; nuclear organization
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.
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