期刊
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
卷 311, 期 23, 页码 2387-2396出版社
AMER MEDICAL ASSOC
DOI: 10.1001/jama.2014.5616
关键词
-
资金
- National Institutes of Health (NIH) [UO1AG22376]
- National Institute on Aging
- National Heart, Lung, and Blood Institute [3U01AG022376-05A2S]
- Intramural Research Program
- Claude D. Pepper Older Americans Independence Centers at the University of Florida [1 P30 AG028740]
- Wake Forest University [1 P30 AG21332]
- Tufts University [1P30AG031679]
- University of Pittsburgh [P30 AG024827]
- Yale University [P30AG021342]
- NIH/NCRR CTSA at Stanford University [UL1 RR025744]
- NIH/NCRR CTSA at University of Florida [U54RR025208]
- NIH/NCRR CTSA at Yale University [UL1 TR000142]
- Boston Rehabilitation Outcomes Center [1R24HD065688-01A1]
- National Institute on Aging [K07AG3587]
- Department of Veterans Affairs
- US Department of Agriculture [58-1950-0-014]
IMPORTANCE In older adults reduced mobility is common and is an independent risk factor for morbidity, hospitalization, disability, and mortality. Limited evidence suggests that physical activity may help prevent mobility disability; however, there are no definitive clinical trials examining whether physical activity prevents or delays mobility disability. OBJECTIVE To test the hypothesis that a long-term structured physical activity program is more effective than a health education program (also referred to as a successful aging program) in reducing the risk of major mobility disability. DESIGN, SETTING, AND PARTICIPANTS The Lifestyle Interventions and Independence for Elders (LIFE) study was a multicenter, randomized trial that enrolled participants between February 2010 and December 2011, who participated for an average of 2.6 years. Follow-up ended in December 2013. Outcome assessors were blinded to the intervention assignment. Participants were recruited from urban, suburban, and rural communities at 8 centers throughout the United States. We randomized a volunteer sample of 1635 sedentary men and women aged 70 to 89 years who had physical limitations, defined as a score on the Short Physical Performance Battery of 9 or below, but were able to walk 400 m. INTERVENTIONS Participants were randomized to a structured, moderate-intensity physical activity program (n = 818) conducted in a center (twice/wk) and at home (3-4 times/wk) that included aerobic, resistance, and flexibility training activities or to a health education program (n = 817) consisting of workshops on topics relevant to older adults and upper extremity stretching exercises. MAIN OUTCOMES AND MEASURES The primary outcome was major mobility disability objectively defined by loss of ability to walk 400 m. RESULTS Incident major mobility disability occurred in 30.1%(246 participants) of the physical activity group and 35.5%(290 participants) of the health education group (hazard ratio [HR], 0.82 [95% CI, 0.69-0.98], P = .03). Persistent mobility disability was experienced by 120 participants (14.7%) in the physical activity group and 162 participants (19.8%) in the health education group (HR, 0.72 [95% CI, 0.57-0.91]; P = .006). Serious adverse events were reported by 404 participants (49.4%) in the physical activity group and 373 participants (45.7%) in the health education group (risk ratio, 1.08 [95% CI, 0.98-1.20]). CONCLUSIONS AND RELEVANCE A structured, moderate-intensity physical activity program compared with a health education program reduced major mobility disability over 2.6 years among older adults at risk for disability. These findings suggest mobility benefit from such a program in vulnerable older adults.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据