期刊
MONATSHEFTE FUR CHEMIE
卷 146, 期 10, 页码 1699-1705出版社
SPRINGER WIEN
DOI: 10.1007/s00706-015-1448-1
关键词
Nortopsentins A-C; Hamacanthin B; Zibotentan (ZD4054); Bisindoles; 1,3,4-Oxadiazoles; Cytotoxicity
A series of ten 1,3,4-oxadiazole-linked bisindole derivatives have been synthesized. All compounds were evaluated for anticancer activity against four human cancer cell lines (MCF-7, KB, Colo-205, and A-549). Most of these new compounds exhibited significant anticancer activity as compared to etoposide. Compounds' GI(50) values range from < 0.1 to 3.9 mu M, while the positive control etoposide has a GI(50) in the range of 0.13-3.08 mu M in the cell lines employed. Among them, four compounds showed a higher activity than etoposide.
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