期刊
MOLECULES
卷 20, 期 10, 页码 18551-18564出版社
MDPI AG
DOI: 10.3390/molecules201018551
关键词
Swietenia macrophylla; Meliaceae; structure elucidation; limonoid; anti-inflammatory activity
资金
- Zuoying Branch of Kaohsiung Armed Forces General Hospital [ZBH 104-21, ZAFGH 102-31]
- Ministry of Science and Technology, Taiwan [NSC 101-2320-B-127-001-MY3]
A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2-6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC50 values 45.44 M) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC50 values 36.32 M, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.
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