期刊
MOLECULES
卷 20, 期 1, 页码 1475-1494出版社
MDPI AG
DOI: 10.3390/molecules20011475
关键词
hypervalent iodine; ring expansion; rearrangement; seven-membered ring; antiproliferative activity
资金
- FAPESP [2010/16042-6, 2012/10568-1]
- CAPES
- CNPq
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/10568-1] Funding Source: FAPESP
A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven-and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether) mediated by the hypervalent iodine reagent HTIB (PhI(OH)OTs). Reaction conditions can be easily adjusted to give ring expansion products bearing different functional groups. A route to medium-ring lactones was also developed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据