期刊
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
卷 302, 期 9, 页码 947-954出版社
AMER MEDICAL ASSOC
DOI: 10.1001/jama.2009.1267
关键词
-
资金
- Programme Hospitalier de Recherche Clinique (French Ministry of Health)
- Assistance Publique-Hopitaux de Paris (AP-HP)
- A. C. T. I. O. N. group (Academic Research Organization)
- Eli Lilly
Context International guidelines recommend an early invasive strategy for patients with high-risk acute coronary syndromes without ST-segment elevation, but the optimal timing of intervention is uncertain. Objective To determine whether immediate intervention on admission can result in a reduction of myocardial infarction compared with a delayed intervention. Design, Setting, and Patients The Angioplasty to Blunt the Rise of Troponin in Acute Coronary Syndromes Randomized for an Immediate or Delayed Intervention (ABOARD) study, a randomized clinical trial that assigned, from August 2006 through September 2008 at 13 centers in France, 352 patients with acute coronary syndromes without ST-segment elevation and a Thrombolysis in Myocardial Infarction (TIMI) score of 3 or more to receive intervention either immediately or on the next working day (between 8 and 60 hours after enrollment). Main Outcome Measures The primary end point was the peak troponin value during hospitalization; the key secondary end point was the composite of death, myocardial infarction, or urgent revascularization at 1-month follow-up. Results Time from randomization to sheath insertion was 70 minutes with immediate intervention vs 21 hours with delayed intervention. The primary end point did not differ between the 2 strategies ( median [interquartile range] troponin I value, 2.1 [0.3-7.1] ng/mL vs 1.7 [0.3-7.2] ng/mL in the immediate and delayed intervention groups, respectively; P=.70). The key secondary end point was observed in 13.7% (95% confidence interval, 8.6%-18.8%) of the group assigned to receive immediate intervention and 10.2% ( 95% confidence interval, 5.7%-14.6%) of the group assigned to receive delayed intervention (P=.31). The other end points, as well as major bleeding, did not differ between the 2 strategies. Conclusion In patients with acute coronary syndromes without ST-segment elevation, a strategy of immediate intervention compared with a strategy of intervention deferred to the next working day ( mean, 21 hours) did not result in a difference in myocardial infarction as defined by peak troponin level. Trial Registration clinicaltrials.gov Identifier: NCT00442949 JAMA.2009;302(9):947-954 www.jama.com
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据