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Ursolic acid causes DNA-damage, P53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo
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被撤回的出版物: Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors EVIDENCE FOR THE ROLE OF REACTIVE OXYGEN SPECIES AND JNK (Retracted article. See vol. 291, pg. 16924, 2016)
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Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORλt Protein
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Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
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Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells
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Uncoupling and Antioxidant Effects of Ursolic Acid in Isolated Rat Heart Mitochondria
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Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways
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Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains
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Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes
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ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2010)
Accumulation of Betulinic, Oleanolic, and Ursolic acids in In vitro Cell Cultures of Lantana camara L. and their Significant Cytotoxic Effects on HeLa Cell Lines
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Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF-κB Pathway Activation
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CEREBRAL CORTEX (2010)
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CURRENT HIV RESEARCH (2010)
Antiangiogenic Activity of Ursolic Acid
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INTEGRATIVE CANCER THERAPIES (2010)
Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-κB using ursolic acid
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INTERNATIONAL JOURNAL OF CANCER (2010)
Oleanolic Acid and Ursolic Acid Induce Apoptosis in HuH7 Human Hepatocellular Carcinoma Cells through a Mitochondrial-Dependent Pathway and Downregulation of XIAP
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)
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Liza J. Raggatt et al.
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Ursolic Acid Overcomes Bcl-2-Mediated Resistance to Apoptosis in Prostate Cancer Cells Involving Activation of JNK-Induced Bcl-2 Phosphorylation and Degradation
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JOURNAL OF CELLULAR BIOCHEMISTRY (2010)
Ursolic Acid Induces PC-3 Cell Apoptosis via Activation of JNK and Inhibition of Akt Pathways In Vitro
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MOLECULAR CARCINOGENESIS (2010)
Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling
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MOLECULAR NUTRITION & FOOD RESEARCH (2010)
Protective effects of Ursolic acid and Luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells
Alice A. Ramos et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2010)
Antitumor Effects of Ursolic Acid in a Mouse Model of Postmenopausal Breast Cancer
Rebecca E. De Angel et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2010)
Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives
Wilson R. Cunha et al.
PHARMACEUTICAL BIOLOGY (2010)
Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis
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ANTI-CANCER DRUGS (2009)
Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species
Huang-Yao Tu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells
Cristina P. R. Xavier et al.
CANCER LETTERS (2009)
Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention
Magdalena C. Kowalczyk et al.
CARCINOGENESIS (2009)
Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells
Xianghong Wang et al.
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2009)
Ursolic Acid Inhibits IL-1β or TNF-α-Induced C6 Glioma Invasion Through Suppressing the Association ZIP/p62 With PKC-ζ and Downregulating the MMP-9 Expression
Hsiu-Chen Huang et al.
MOLECULAR CARCINOGENESIS (2009)
Pentacyclic Triterpene Distribution in Various Plants - Rich Sources for a New Group of Multi-Potent Plant Extracts
Sebastian Jaeger et al.
MOLECULES (2009)
Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy
Melanie N. Laszczyk
PLANTA MEDICA (2009)
FOXM1 Upregulation Is an Early Event in Human Squamous Cell Carcinoma and it Is Enhanced by Nicotine during Malignant Transformation
Emilios Gemenetzidis et al.
PLOS ONE (2009)
Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines
Irene Bonaccorsi et al.
CANCER LETTERS (2008)
Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells
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INTERNATIONAL IMMUNOPHARMACOLOGY (2008)
Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes
Stephane Fontanay et al.
JOURNAL OF ETHNOPHARMACOLOGY (2008)
Antioxidative and anti-inflammatory protection of oleanolic acid and ursolic acid in PC12 cells
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JOURNAL OF FOOD SCIENCE (2008)
Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo
Su-Ui Lee et al.
PHARMACOLOGICAL RESEARCH (2008)
Ursolic Acid and Oleanolic Acid Suppress Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon
Ricardo A. Furtado et al.
TOXICOLOGIC PATHOLOGY (2008)
Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats
David Andersson et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2008)
Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose
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BIOCHEMICAL PHARMACOLOGY (2007)
Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells
E. Kassi et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2007)
Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRIE)
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BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)
Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)
Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation
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CANCER RESEARCH (2007)
Protective effect of ursolic acid against myocardial ischemia induced by isoproterenol in rats
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TOXICOLOGY MECHANISMS AND METHODS (2007)
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells (Publication with Expression of Concern. See vol. 16, pg. 1442, 2018)
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Bioassay-guided isolation of antimalarial triterpenoid acids from the leaves of Morinda lucida
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PHARMACEUTICAL BIOLOGY (2006)
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Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta
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LIFE SCIENCES (2006)
Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production
SF Ahmad et al.
PHARMACOLOGICAL RESEARCH (2006)
Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana
Ze Tian et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2006)
Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats
R Saravanan et al.
LIFE SCIENCES (2006)
Ursolic acid inhibits neointima formation in the rat carotid artery injury model
M Pozo et al.
ATHEROSCLEROSIS (2006)
Biogenesis, molecular regulation and function of plant isoprenoids
F Bouvier et al.
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Oleanolic acid and ursolic acid: Research perspectives
H Liu
JOURNAL OF ETHNOPHARMACOLOGY (2005)
Polyisoprenoids: Structure, biosynthesis and function
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Inhibition of endogenous reverse transcriptase antagonizes human tumor growth
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ONCOGENE (2005)
The cytotoxic activity of ursolic acid derivatives
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2005)
Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis
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Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells
PO Harmand et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer
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Effects of ursolic acid on different steps of the angiogenic process
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Ursolic acid protects hippocampal neurons, against kainate-induced excitotoxicity in rats
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NEUROSCIENCE LETTERS (2004)
Antimicrobial activity of some pentacyclic Triterpenes and their synthesized 3-O-lipophilic chains
UV Mallavadhani et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2004)
Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension
LO Somova et al.
PHYTOMEDICINE (2003)
Antitumor activity of compounds isolated from leaves of Eriobotrya japonicai
H Ito et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2002)
Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells
DM Both et al.
ARCHIVES OF DERMATOLOGICAL RESEARCH (2002)
Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes
S Martin-Aragón et al.
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2001)
Topical anti-inflammatory activity of Salvia officinalis L. leaves:: the relevance of ursolic acid
D Baricevic et al.
JOURNAL OF ETHNOPHARMACOLOGY (2001)
Inflammation and cancer: back to Virchow?
F Balkwill et al.
LANCET (2001)
Nuclear events in apoptosis
JD Robertson et al.
JOURNAL OF STRUCTURAL BIOLOGY (2000)
Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
SC Manolagas
ENDOCRINE REVIEWS (2000)